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Ms Clarke is apart from the minor surgical problem, she is fit, active and apparently healthy. However, she tells you she is really worried about the operation because she had a bad experience with an operation when she was a child. Ms Clarke cannot quite remember the details, but she says that when she came round from the previous operation she couldnt move and can remember being scared. What do you think might have happened to Ms. Clarke after the previous operation.

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General Function Inhibitory extracellular ligand-gated ion channel activity Specific Function Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Targets 3. General Function Arylamine n-acetyltransferase activity Specific Function Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Let's Go! U Nuclear receptor subfamily 1 group I member 2.

Epub Nov General Function Vitamin d3 hydroxylase activity Specific Function Cytochromes P are a group of heme-thiolate monooxygenases. Take the tour. J Pharmacol Exp Ther. Interactions Drug Interactions Food Interactions. Epub Jun General Function Zinc ion binding Specific Function Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds.

Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse Label 11, 12, 13, Clonazepam is indicated as monotherapy or as an adjunct in the treatment of Lennox-Gastaut syndrome petit mal variant, akinetic, and myoclonic seizures Label Furthermore, clonazepam may also be of some value in patients with absence spells petit mal who have failed to respond to succinimides Label Additionally, clonazepam is also indicated for the treatment of panic disorder, with or without agoraphobia, as defined in the DSM-V Label.

Clonazepam is rapidly and almost entirely absorbed after oral administration as tablets Label 12, Peak plasma concentrations of clonazepam administered by the oral route are reached within hours and the associated absorption half-life is about 25 minutes Label 12, Clonazepam distributes very rapidly to various organs and body tissues with preferential uptake by brain structures 12, Clonazepam is metabolized principally in the liver 12, The metabolic pathways include hydroxylation, reduction of the nitro groups to amine groups, and the addition of acetate to the amino grouping 12, In particular, clonazepam is extensively metabolized by reduction to 7-amino-clonazepam and by N-acetylation to 7-acetamido-clonazepam 12, Hydroxylation at the C-3 position also occurs 12, Metabolites of clonazepam are present in urine as both free and conjugated glucuronide and sulfate compounds 12, The mean elimination half-life determined for clonazepam is independent of the dose given and has been documented as being about hours 12, Nevertheless, clearance values normalized by weight decline with increasing body weight Benzodiazepines like clonazepam commonly cause drowsiness, ataxia, dysarthria, and nystagmus.

Epub Oct 4. Evidence Level. Anal Bioanal Chem. Drug Metab Lett. By enhancing the neuro-inhibitory activity of GABA, it is believed that clonazepam can facilitate in decreasing any excessive electrical nerve activity in the CNS that might be contributing to seizures 8. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Overdose with clonazepam is generally not life-threatening if the drug is taken alone, but may lead to areflexia, apnea, hypotension, cardiorespiratory depression, and coma.

Benzodiazepine respiratory depressant effects are more serious when compounded in patients with respiratory disease. A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop Label 11, 12, 13, The agent has also been indicated for treating panic disorder Label 7, 11, 12, 13, The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses Label 7, 8, 11, 12, 13, Since being first patented in and then released for sale from Roche in the US in 9, 10, clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions.

When GABA binds to GABA a receptors found in neuron synapses, chloride ions are conducted across neuron cell membranes via an ion channel in the receptors 6, 7, 8, With enough chloride ions conducted, the local, associated neuron membrane potentials are hyperpolarized - making it more difficult or less likely for action potentials to fire, ultimately resulting in less excitation of the neurons 6, 7, 8, Subsequently, benzodiazepines like clonazepam can bind to benzodiazepine receptors that are components of various varieties of GABA a receptors 6, 7, 8, 13, 11, Combined with the notion that such benzodiazepine receptor associated GABA a receptors exist both peripherally and in the CNS, this activity consequently facilitates various effects like sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action 6, 7, 8, 13, 11, In particular, when out of the ordinary rapid and repetitive electrical signals are released in the CNS, it is proposed that the brain can become over-stimulated and ordinary functions are disrupted - resulting in seizure activity 8.

Application Number. Fundam Clin Pharmacol. Drug Interaction. Epub Mar J Biol Chem. Enzymes 3. Clinical Trials.

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