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The magnitude of the response to a given dose of a drug in a population of patients shows a normal distribution. The vast majority, approximately within acceptable limits.
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- Reference Department of Health Review of Prescribing, Supply and Administration of Medicines; Final report, Department of Health, London.
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Depot preparations are designed to give a slow sustained release of drug. Drugs injected intravenously go directly into the blood stream and are rapidly distributed around the body.
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Other effects include reduction in tone and motility of the gastrointestinal tract, producing constipation, and the release of histamine from mast cells, causing local pain and itching at the injection site. Histamine released systemically may induce bronchoconstriction, bradycardia and hypotension.
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