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There may be involvement of defective nicotinic receptors because the use of transdermal nicotine patches has been shown to improve some symptoms of the disorder. Behavioural therapy or counselling may be helpful in some individuals with ADHD. Psychostimulant drugs are used to treat ADHD, where paradoxically they have a calming effect and improve concentration and attentiveness in about should be under the guidance of a specialist in ADHD. Examples of drugs used to treat ADHD are dexamfetamine, methylphenidate and atomoxetine. These drugs inhibit the re-uptake of noradrenaline and dopamine.

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The magnitude of the response to a given dose of a drug in a population of patients shows a normal distribution. The vast majority, approximately within acceptable limits.

  • Recovery from etomidate is rapid with no hangover.
  • Reference Department of Health Review of Prescribing, Supply and Administration of Medicines; Final report, Department of Health, London.
  • Sickle cells block blood vessels, cause pain and impair circulation.
  • The pain and swelling of gout is caused by the deposition of uric acid crystals in the joint.
  • In addition, serum markers of disease progression are reduced.

Both methotrexate and mercaptopurine are used to treat acute leukaemia. Fluorouracil is a pyrimidine analogue that substitutes for uracil in the synthesis pathway for thymidylate, a necessary step in the synthesis of DNA.

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Depot preparations are designed to give a slow sustained release of drug. Drugs injected intravenously go directly into the blood stream and are rapidly distributed around the body.

Vancomycin also inhibits cell wall synthesis by a slightly different mechanism at an earlier stage. This antibiotic is still effective against most strains of MRSA and has to be given intravenously because it is not absorbed well enough to be effective orally. It is useful in patients who are allergic to penicillin. Adverse reactions to vancomycin are fever, rashes and rarely ear and kidney toxicity. Adverse effects of aminoglycosides are deafness, kidney damage and allergy.

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Other effects include reduction in tone and motility of the gastrointestinal tract, producing constipation, and the release of histamine from mast cells, causing local pain and itching at the injection site. Histamine released systemically may induce bronchoconstriction, bradycardia and hypotension.

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