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Thus, each receptor has two binding sites and both must be occupied for the receptor to be activated. Receptors for some other neurotransmitters, for example gamma-aminobutyric acid and glutamate, are believed to be similar. This type of receptor controls the transient increase in postsynaptic membrane permeability to a particular ion at the synapse. This is a rapid event, occurring in milliseconds, which indicates that the receptor is directly connected to the channel. These are receptors for many hormones and neurotransmitters and are coupled to effector systems by a G-protein.
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