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Grieving is a natural process that serves a purpose in recovery from loss. It is important to realize that some medical conditions can mimic the symptoms of generalized anxiety disorder, for example hyper- or hypothyroidism, hypoglycaemia, drug or alcohol withdrawal and cardiac arrhythmias. Anxiety and fear are both associated with general arousal of the CNS and may be due to over activity in the RAS. Neurotransmitters in the RAS are serotonin and GABA. It is thought that GABA normally moderates the activity of serotonin-containing neurons and that in anxiety syndromes some of this moderation is lost due to changes in receptor sensitivity, or due to overactivity of a natural inhibitor of GABA. An inhibitor of GABA has not been identified, but it has been tentatively called GABA modulin.
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Metabolism usually makes a drug more water soluble and less pharmacologically active. Distribution to the rest of the body depends on how well a drug can pass across cell membranes.
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Phenytoin and carbamazepine have been shown to block sodium ion channels, thus reducing the excitability of the neuronal membrane. Sodium ion channels can be in three different states open, closed or inactive.
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