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Once back in the small intestine the original drug can be reabsorbed.
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It is not absorbed orally so, unless it is being used to treat gastrointestinal infections, it has to be given by intravenous injection.
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When used prophylactically, tolerance may develop to the vasodilator effects of nitrates. To avoid this, patients have to have drug free periods each day, when they know they are least likely to suffer and angina attack.
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