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A year-old woman with chronic back pain found relief by taking carisoprodol, a centrally acting skeletal muscle relaxant. She then abruptly stopped the medication and presented to the emergency room one week later with waxing and waning attention, confusion, disorientation and visual hallucinations. Her symptoms of delirium resolved rapidly and she was discharged home on day three. Such withdrawal symptoms could be expected as the mechanism of action of carisoprodol is similar to that of hypnotic sedatives. Its availability and ease with which it can be acquired through the Internet puts it at great risk for a drug of abuse. Carisoprodol is a skeletal muscle relaxant that exerts its effect via sedation of the central nervous system rather than through direct muscle relaxation Littrell et al Animal studies have demonstrated that carisoprodol blocks interneurons and depresses transmission of polysynaptic neurons in the spinal cord and descending reticular system of the brain.
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Blood pressure is highest in the aorta and reduces in blood vessels further away from the heart until it reaches As the heart and circulation is a closed system, the blood pressure is maintained with each contraction of the ventricles. Blood pressure depends on the total volume of blood in the system and on the resistance provided by all the blood vessels.
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Bronchioles are supported by smooth muscle, which allows their diameter to change. In all, there are about are reached. The terminal bronchioles divide into alveolar ducts at the end of which are tiny thin walled air sacs, the alveoli. The alveoli present an enormous surface area for gas exchange. Surrounding the alveoli are many blood capillaries. Oxygen in the air that is breathed into the lungs diffuses from the alveoli across their thin walls into tissue fluid and then into the blood capillaries.
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Examples of vinca alkaloids are vinblastine, vincristine and vindesine. These drugs are used to treat leukaemia, lymphoma, testicular cancer and lung cancer.
Its mode of action is by enhancement of inhibitory actions of GABA in the brain. Thiopental is an anaesthetic but has no analgesic action; indeed, it may increase perception of pain.