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This led to the withdrawal of rofecoxib in October for patients at high risk of developing gastrointestinal side effects. All NSAIDs are contraindicated in patients with active peptic ulceration and in those who have a history of hypersensitivity to any NSAID. They should be used with caution in older people (because of the risk of serious gastrointestinal side effects and drug-induced hepatitis), in allergic disorders including asthma, during pregnancy and in coagulation disorders. Because of the risk of serious side effects with long-term use, treatment of rheumatic disease with corticosteroids is controversial. They should generally be reserved for patients in whom other anti-inflammatory drugs are unsuccessful or until other drugs take effect (see DMARDs below).
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If the corticosteroid drugs are stopped and the adrenal glands are no longer able to produce sufficient natural corticosteroids, the body will be unable to withstand every day stresses, a situation that can be life threatening. Anti-inflammatory corticosteroids depress the immune system.
Authored by Dr. Amit M. Patel, MD, DABA, DABAPM
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Venlafaxine selectively inhibits the re-uptake of both serotonin and noradrenaline.
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Corticosteroids suppress all phases of the inflammatory response, including the early swelling, redness and pain and the later stages seen in chronic inflammation. Circulating lymphocytes and macrophages are reduced in number and the formation of prostaglandins and leukotrienes is inhibited via inhibition of phospholipase A enzyme that converts cell membrane phospholipids into arachidonic acid.
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Cytarabine is a pyrimidine analogue, which is incorporated into both RNA and DNA and interferes with the action of DNA polymerase. Cytarabine is used to treat leukaemia.
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Drugs injected subcutaneously or intramuscularly have to diffuse between loose connective tissue or muscle fibres.
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In people with gout, the uric acid level in the blood exceeds its solubility and crystals are deposited in joints and other tissues.
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