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This chapter discusses the processes of administration, absorption, distribution, metabolism and excretion of drugs together with factors affecting these processes. Collectively, these processes describe drug disposition, the way in which the body handles drugs. The study of the fate of drugs in the body is known as pharmacokinetics. In order to get to their site of action in the body, drugs have to be administered in some way. There are two major routes of drug administration: enteral and parenteral. Enteral means to do with the gastrointestinal tract and includes oral and rectal administration.

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The rate at which a drug is metabolized will affect its distribution. Similarly the rate of elimination or excretion also affects distribution and vice versa.

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A community physiotherapist treating a patient in a remote location who is not responding well to medicines prescribed by a consultant could, under a CMP, alter dosages for that patients benefit.

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