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Ten years ago, the multinational pharmaceutical company AstraZeneca launched what was known inside the company as the Shark Fin Project. The team for the project was composed of lawyers, marketers, and scientists, and its focus was a prescription drug known as Prilosec, a heartburn medication that, in one five-year stretch of its extraordinary history, earned AstraZeneca twenty-six billion dollars. The patent on the drug was due to expire in April of The Shark Fin team drew up a list of fifty options. One idea was to devise a Prilosec 2. In some cases, removing one of the isomers can reduce side effects or make a drug work a little bit better, and in all cases the Patent Office recognizes something with one isomer as a separate invention from something with two. So AstraZeneca cut Prilosec in half.

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Industry-specific and extensively researched technical data partially from exclusive partnerships. AstraZeneca's top products based on revenue AstraZeneca's revenue from top product Nexium AstraZeneca's revenue from top product Crestor This feature is limited to our corporate solutions.

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Frequently bought with Warnings Allergy alert: Do not use if you are allergic to esomeprazole.

  • These signs and symptoms may indicate your child has GERD gastroesophageal reflux disease.
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These are abnormalities of movement that resemble Parkinsons disease (see page Anti-psychotics that also have anti-cholinergic activity cause fewer Parkinsonian side effects. A more serious and irreversible side effect related to Parkinsonism is tardive dyskinesia. This occurs after many years of anti-psychotic drug use and is characterized by abnormal and disabling involuntary movements of the face, tongue, trunk and limbs. Phenothiazines have pronounced sedative effects. They are also antiemetic (due to the blocking of dopamine receptors in the chemotrigger zone) and cause increased levels of prolactin (by inhibition of the effects of dopamine in the hypothalamic-pituitary pathway, and women. This group of drugs is similar to phenothiazines with mode of action lisinopril 25mg block of dopamine D are very similar.


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The β-adrenoreceptor was the first of this type to be characterized and others seem to be similar.

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The mode of action of calcipotriol in psoriasis is apparently unconnected to the role of vitamin D in calcium metabolism.

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This is often at odds with their intended therapeutic use, but nevertheless is what generally happens.

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Keratin is a tough fibrous protein. Keratinocytes of the epidermis are arranged into four or five layers.

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Following oral administration, griseofulvin is sequestered into the keratin of skin and nails.

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