As an antianxiety drug, Librium was a great success. Three year later, in, Valium appeared on the market. Not only the leading hitter in the benzodiazepine lineup, this drug also become one of the best selling of all pharmaceuticals ever! Valium diazepam extended its therapeutic uses beyond anxiety to insomnia, muscle spasms, acute alcohol withdrawal, and preoperatve sedation, and, via injection, to control status epilepticus, a life-threatening condition in which seizures presist without letupfor more than thirty minutes. For many of these conditions, it represented the first or seconf drug of choice. In contrast to the barbiturates, Valium caused less drownsiness at normal therapeutic doses, thereby not impairing mental or physical function. However, even safe drugs have limits.

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Criminal gangs are selling fake Valium online at a fraction of the cost of genuine tablets, leading people to take potentially lethal doses of illicitly-produced drugs, according to a leading addiction treatment service. People discuss it on Mumsnet. The danger is of course that people are buying unknown concentrations and possibly even unknown drugs. Some of the fake diazepam 5mg yellow tablet contain alternatives to diazepam, such as Etizolam, which, while producing similar effects, can be lethal if mixed with heroin or methadone. But Bremner said the problem was moving south.

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They are more effective in treatment of the immediate phase reaction than the late phase reaction. β stimulants are less effective in chronic bronchitis, possibly because in this disease bronchoconstriction is due to reflex stimulation of acetylcholine receptors following stimulation of local irritant receptors in lung tissue. There are many drugs in this group but little to choose between them. They are most often used as aerosol or dry powder inhalers, but are also available as nebulizer solutions, tablets, syrups, injections and intravenous infusions. Examples are salbutamol and salmeterol (long-acting for symptom control at night or before exercise).

The allergen, whether it is a drug, pollen or dust mite, causes production of immunoglobulin E antibodies on first exposure. These antibodies attach themselves to mast cells. On subsequent exposure to the same allergen the combination of IgE and allergen causes the mast cells to release a variety of chemicals including histamine. The effects of this can be local, for example hay fever, asthma and urticaria, or systemic causing whole body oedema and anaphylactic shock. An example of a drug that is known to cause type Radiological contrast agents can also provoke this type of allergic reaction.

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