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Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the body, often reaching their targets through the bloodstream. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and in men. Estrogen promotes the development and maintenance of female sex characteristics and the growth of long bones. Progesterone plays a role in the menstrual cycle and pregnancy. The activated receptors cause changes in the expression of specific genes, which can stimulate cell growth. To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. Most ER-positive breast cancers are also PR positive.

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