Bupropion is used widely as a smoking cessation aid and antidepressant and is available in immediate- and extended-release preparations. It blocks neuronal reuptake of dopamine and norepinephrine and antagonizes acetylcholine at neuronal nicotinic receptors. Nonhealing skin ulcers may reflect surreptitious injection of crushed tablets. For all cases of bupropion overdose, seizures should be anticipated and a poison control centre consulted. Treatment with activated charcoal should be considered for patients presenting within 60 minutes of ingestion in whom the risk of aspiration is low. Nathan Stall. Bupropion is a commonly used antidepressant and smoking cessation aid Bupropion is used widely as a smoking cessation aid and antidepressant and is available in immediate- and extended-release preparations.

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A year-old male with past medical history of substance abuse presented to the emergency department for bupropion overdose. Conclusion Bupropion overdose is a well-known cause of seizure with potential deadly cardiovascular effects in extreme overdose 18,

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A year-old male with past medical history of substance abuse presented to the emergency department for bupropion overdose. He was last seen normal prior to going to bed. Just cheapest elontril to arrival his girlfriend woke to find him sitting up against a wall in the bedroom with multiple empty bottles of bupropion XL. He appeared altered, had pill residue in both nares and on his lips, and was noted to have brief, generalized, seizure-like activity lasting less than 10 seconds that extinguished on its own. On arrival the patient was alert but disoriented to place and time. On physical exam his pupils were 3 mm equal round and reactive, no nystagmus was noted, his tone was normal, but he had non-extinguishing clonus of his lower extremities.

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Bupropion is a member of the miscellaneous antidepressants drug class and is commonly used for ADHD, Anxiety, Bipolar Disorder, and others. Prices are for cash paying customers only and are not valid elontril cheap insurance plans. Important: When there is a range of pricing, consumers should normally expect to pay the lower price. The free Drugs. There are currently no Manufacturer Promotions that we know about for this drug.

Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. When used as an aid to smoking cessation, bupropion is thought to confer its anti-craving and anti-withdrawal effects by inhibiting dopamine reuptake, which is thought to be involved in the reward pathways associated with nicotine, and through the antagonism of the nicotinic acetylcholinergic receptor. Bupropion is sometimes used as an add-on agent to first-line treatments of depression such as selective serotonin reuptake inhibitor SSRI medications when there is a treatment-failure or only partial response. This includes the hypothalamus, which is involved in appetite regulation, and the mesolimbic dopamine circuit, which is involved in reward pathways. Bupropion is indicated for the treatment of major depressive disorder MDD, seasonal affective disorder SAD, and as an aid to smoking cessation. Bupropion is also used off-label as a first-line treatment in patients with ADHD and comorbid bipolar disorder when used as an adjunct to mood stabilizers.

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This still does not explain the swings in mood and little is known about how or why alternation between depression and mania occurs. Patients with unipolar depression are effectively treated with drugs, such as chlorimipramine and more recently fluoxetine, which are known to block neuronal uptake of serotonin. In addition, giving alone or in combination with chlorimipramine seems to benefit these patients. Evidence against this serotonin theory includes the fact that low levels of ( have recovered and in some patients with mania. It seems likely that low levels of serotonin or noradrenaline do not cause depression, but that more complicated mechanisms involving a change in balance between these monoamines are involved. Despite evidence for and against, there remains one major problem with the monoamine theory of depression.

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