Taxi drivers outside the hotel and other hotels know the way to Tengenenge. Tengenenge lies in the North, between Mvurwi and Guruve, about km north of Harare. The travel takes about 2 hours. Bring a bottle of mineral water for on the road! Prices of the taxies vary; it is possible to negotiate. In Mvurwi you take the road to Guruve, until the sign to the right with Art Centre on it.

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It is recommended that treatment is started while the patient is still smoking and a target stop date set within the first two weeks of treatment with Zyban, preferably in the second week. The initial dose is mg to be taken daily for six days, increasing on day seven to mg twice daily. The maximum single dose must not exceed mg and the maximum total daily dose must not exceed mg. Insomnia is a very common adverse event which can be reduced by avoiding bedtime doses of Zyban provided there is at least 8 hours between doses. Use in patients under 18 years of age is not recommended as the safety and efficacy of Zyban tablets have not been evaluated in these patients. Zyban should be used with caution in older people. Greater sensitivity in some older individuals cannot be ruled out. The recommended dose in older people is mg once a day see section 4. Zyban should be used with caution in patients with hepatic impairment. Because of increased variability in the pharmacokinetics in patients with mild to moderate impairment the recommended dose in these patients is mg once a day.

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It was when he became a father that Michael Briggs resolved to somehow bring his ulcerative colitis under control. He was determined to avoid what many people with the disease end up needing — having part or all of their large intestine removed. The problem is that drugs like this can have significant side effects, such as leaving patients more prone to infections and, in rare cases, cancer. Doctors all over the world are allowed to prescribe drugs off-label, and antidepressants are used for several conditions and diseases beyond depression, including migraines, hot flushes, attention deficit hyperactivity disorder ADHD and disorders of the digestive system. Off-label use means that more potentially effective treatments have a chance of becoming available in medical practice.

Costs based on the additional physician time required and retail prices of the medications. Tobacco kills four million people worldwide each year and is presently one of the leading causes of avoidable premature death in the developed world. Furthermore, previous economic studies of smoking cessation have used different methods and assumptions for estimating costs and effectiveness, making comparison between studies difficult. We supposed that GPs provided their smoking patients opportunistic cessation counselling during routine office visits and offered pharmacotherapy to those for whom it was indicated. The reference cohort received only cessation counselling from a GP. The second cohort received the same counselling plus each of the five pharmacotherapies.

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