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There are some newer drugs recently added or in development. Sulfonylureas work by stimulating remaining functional β-cells in the islets of the pancreas so that insulin is secreted in response to normal stimuli.

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An episode of gout can be triggered by excessive alcohol consumption, a diet high in purines, surgery, sudden severe illness, injury to a joint, use of diuretics or chemotherapy. Over several years, uric acid crystals can build up in other tissues to form large deposits, called tophiunder the skin.

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