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Genital herpes severe initial episodes in immunocompetent patients. Close more info about Acyclovir Inj.

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In addition, oral Acyclovir Zovirax provided effective prophylaxis for herpes virus disease. Injection: Acyclovir Zovirax IV for infusion is indicated for the treatment of herpes simplex infections, prophylaxis of herpes simplex infections in immune-compromised patients, treatment of varicella zoster infections, herpes simplex infections in the neonate. Special Precautions: Infusion: In patients receiving Zovirax IV for infusion at higher doses eg, for herpes encephalitis, specific care regarding renal function should be taken, particularly when patients are dehydrated or have any renal impairment. Reconstituted Acyclovir Zovirax IV for infusion has a pH of approximately 11 and should not be administered by mouth. Hydration Status: Tablet: Care should be taken to maintain adequate hydration in patients receiving high oral doses of acyclovir. Further, a detrimental effect on such activities cannot be predicted from the pharmacology of the active substance. SKU: Contraindications: Hypersensitivity to acyclovir or valacyclovir. Products You May Like

Author Details. Radhika Dua. Shilpa Garcha. Zovirax mg Infusion. Glaxo SmithKline Pharmaceuticals Ltd. Acyclovir mg.

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Error: This is required. Error: Not a valid value. Promoting resolution of acute manifestations of mucocutaneous Herpes simplex virus in immunocompromised patients. Treatment of severe initial or primary genital herpes in immune competent patients. Treatment of acute manifestations of Varicella zoster virus infection in immunocompromised patients. The use of the intravenous infusion may be warranted in only a small subgroup of immune competent patients.

Acyclovir sodium for injection is a sterile lyophilized powder for intravenous administration only. The quantitative relationship between the in vitro susceptibility of herpes viruses to antivirals and the clinical response to therapy has not been established in humans, and virus sensitivity testing has not been standardized. ZOVIRAX for Injection is indicated for the treatment of severe initial clinical episodes of herpes genitalis in immunocompetent patients. Obese patients should be dosed at the recommended adult dose using Ideal Body Weight. No supplemental dose appears to be necessary after adjustment of the dosing interval.

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Genital herpes severe initial episodes in immunocompetent patients. Herpes simplex in neonates, and as initial and buy valtrex online ireland treatment in immunocompromised patients. Herpes simplex encephalitis. Varicella zoster immunocompromised patients. Give by IV infusion over 1 hour. Obese: dose based on ideal body weight.

Resistance can occur through a number of consequences of viral mutation. There may be reduced phosphorylation of the drug, alteration of viral enzyme targets, or alteration of target channel protein. These synthetic compounds resemble the natural nucleotides of viral DNA or RNA. They are phosphorylated in infected cells and then compete with the normal nucleotides for incorporation into viral DNA or RNA. This results in irreversible inhibition of viral polymerase. (Note: a nucleoside is a base [either purine or pyrimidine] plus a sugar molecule; a nucleotide is a base plus a phosphorylated sugar molecule.

This is possibly because of its antioxidant properties. However, it is probably better to use alternative methods of investigation, for example ultrasound in high-risk patients. The common conditions predisposing to high risk of renal toxicity with contrast agents are listed below: Pre-existing renal failure Serum creatinine above Hypovolaemia Ventricular dysfunction Hypertension Dehydration Nephrotoxic drugs Diabetes mellitus with renal impairment Advanced age Multiple myeloma Any patient requiring high dose Toxicity is also related to chemical composition of a contrast agent. This is not completely understood, but appears to be related to protein binding capacity of the molecule. Binding of contrast agent to enzymes in particular can inhibit their activity.

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