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They should not be taken at the same time as milk because it impairs their absorption. An example is sodium etidronate. Side effects of bisphosphonates are bone pain and gastrointestinal disturbances. Osteoporosis, literally meaning porous bone, involves a loss of total bone mass and a change in the microstructure of bone. This is usually an age-related process that is accelerated in post-menopausal women due to oestrogen deficiency.

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Adverse effects include photosensitivity and skin reactions and the rare but more serious risk of pulmonary fibrosis.

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The oral route requires a co-operative and conscious patient. Rectal administration avoids drug inactivation by stomach acid and digestive enzymes and about circulation.

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Examples of xanthine bronchodilators are theophylline and aminophylline.

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