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- They were originally developed from mono-iodinated pyridine derivatives (in the reduce toxicity led to tri-iodinated benzene derivatives.
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However, a major problem with MAOI drugs is that they produce a number of potentially fatal interactions with other drugs and common foods. Many foods contain tyramine, for example red wines, some pickled foods, yeast extract, particular cheeses and some vegetables, including soya and broad beans.
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Over the next few years, following the Health and Social Care Act prescribing by nurses and pharmacists was introduced.
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A PGD can include a variable dose range, so the health care professional can decide on a suitable dose for individual patients.
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