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  • Reduction in blood pressure also improves cardiac output.
  • They were originally developed from mono-iodinated pyridine derivatives (in the reduce toxicity led to tri-iodinated benzene derivatives.
  • This approach carries the risk that relapse may occur as the dose is reduced, particularly if this is done too quickly.
  • For treatment of anxiety, benzodiazepines such as diazepam and oxazepam are used because they have a slower onset of action with a longer duration than others.
  • Mood disorders are associated with changes in regional brain function, which is different to those seen in non-depressed patients who feel sad.
  • Their mode of action is complicated by the fact that currently seven serotonin receptor sub-types are recognized, further into is significance of the the brain and most is known about are inhibitory autoreceptors.
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However, a major problem with MAOI drugs is that they produce a number of potentially fatal interactions with other drugs and common foods. Many foods contain tyramine, for example red wines, some pickled foods, yeast extract, particular cheeses and some vegetables, including soya and broad beans.

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Over the next few years, following the Health and Social Care Act prescribing by nurses and pharmacists was introduced.

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A PGD can include a variable dose range, so the health care professional can decide on a suitable dose for individual patients.

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