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In severe cases there may be difficulty in swallowing with the risk of aspirating food into the lungs and difficulty in breathing, due to weakness of the respiratory muscles, which can be life threatening if untreated. Not all muscle groups are affected in all patients, and the disease has a variable progression. In some cases, the first approach to treatment is surgical removal of the thymus gland, providing the patient has reached puberty and is younger than myasthenia gravis have an abnormality of the thymus. Normally the thymus gland is involved in the maturation of T lymphocytes, but in myasthenia gravis it appears to be the site of production of antibodies against the acetylcholine receptors. Thymectomy increases the chances of a patient going into remission, although it may take for the benefits to be seen. Drug therapy has to be tailored to individual patients and includes anticholinesterase drugs, anti-inflammatory corticosteroids and immunosuppressant drugs.

They are intended to stimulate discussion not limit debate. What are the podiatric consequences of Mr Buckleys current drug treatment. Apart from symptomatic treatment, what would you advise the patient to do. How would you hope that the drug therapy of this patient could be altered to maximize the natural healing properties of the patient. You should be able to answer these review questions from the material in the preceding chapter. As with cardiac and blood disorders, respiratory disease is relatively common in many older patients.

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