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Benzodiazepines are commonly used anxiolytics and hypnotics. They act at benzodiazepine receptors that are found close to GABA receptors.
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Small diameter neurons are more susceptible than larger diameter neurons and unmyelinated neurons more than myelinated neurons. Fortunately, neurons that carry the sensation of pain are of the smallest diameter unmyelinated and myelinated type and as such are affected by low doses of local anaesthetic, leaving larger motor neurons unaffected.
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Penicillamine may inhibit production of inflammatory mediators and can delay the progress of disease. It has severe side effects; in particular bone marrow depression, and precipitation of myasthenia gravis and myositis.
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