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A good cannulation technique is essential to avoid extravasation, tissue damage or the introduction of air into the circulation. Air embolism is a rare but life-threatening complication. Techniques that puncture the skin can introduce infection through poor aseptic technique or contaminated equipment. Antihistamines and corticosteroids, if needed for adverse reactions, should never be mixed in the same syringe because precipitation would occur. Contrast agents are among the safest medicinal products in use.

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