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Filariasis causes elephantiasis (blockage of lymphatics and swelling of the limbs) and onchocerciasis causes river blindness in tropical and subtropical countries. Ivermectin has occasional use against round worms, hookworms and whip worms and is available on a named-patient basis in the United Kingdom. Its mode of action is by enhancing GABA mediated inhibition at the neuromuscular junction.
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Pneumocystis pneumonia is an opportunistic lung infection almost exclusively seen in patients with HIV.
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This chapter gives a general overview of the endocrine system.
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Movement of the limbs assumes a typical pattern, often being described as a cogwheel or ratchet movement. The muscles become progressively more rigid and there is decrease in the frequency of voluntary movement.
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