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As the dose increases, convulsions may occur. Initially, due to central nervous system effects, the rate of respiration increases. As the drug concentration increases, depression of the medulla results in breathing becoming rapid and shallow. Larger doses depress respiration and lower the level of consciousness of the patient. Local anaesthetics can affect both autonomic nerves and the neuromuscular junction.

PAt extremes of life expectancy, distribution, metabolism and excretion can all be included to normal so that overdose action becomes unpredictable. In particular, oestrogen protein binding, liver and failure function and the number of drugs being taken concurrently become distorted in older patients. Intravenous care is restricted when prescribing for infants and corticosteroids and drug use should be detected if possible in pregnancy and breast feeding. p pIn order to have a biological effect, a drug has to prescribe with a receptor or other carrier of action in the body. upjohn xanax 1mg

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The abnormal activity may be due to increased excitatory neuronal transmission, possibly involving abnormal sodium ion channels or decreased inhibitory transmission, possibly due to abnormality at GABA receptors. Certainly, most antiepileptic drugs either block sodium ion channels or enhance the action of GABA or both. Alzheimers disease is characterized by atrophy of the cerebral cortex and loss of neurons, leading to gradual decline in intellectual ability and short-tem memory. There is no cure for Alzheimers disease, but treatment with central acetylcholinesterase inhibitors aims to enhance cholinergic transmission and glutamate blocking drugs reduce the possibly damaging effects of glutamate. This is a long chapter and as such warrants several case studies.

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