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It is possible that the RAS can be activated through pathways from the cerebral cortex if a situation is perceived as being threatening. Sleep is complicated and involves the brain stem RAS.
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There may be involvement of defective nicotinic receptors because the use of transdermal nicotine patches has been shown to improve some symptoms of the disorder. Behavioural therapy or counselling may be helpful in some individuals with ADHD.
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Acknowledgements I would like to thank friends and colleagues who encouraged and supported me in the writing of this book from its early inception through to final completion. I especially want to thank Leah Greene for her technical expertise and unfailing assistance with computer applications.
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As the drug concentration increases, depression of the medulla results in breathing becoming rapid and shallow.
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