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An example of a loop diuretic is furosemide. Both thiazides and loop diuretics also produce vasodilation, which reduces peripheral vascular resistance and helps reduce blood pressure. Thiazide diuretics are recommended as an alternative to calcium channel blockers as first choice drugs in hypertensive patients over the age of Adverse effects of diuretics are excessive potassium and hydrogen ion loss leading to hypokalaemia and metabolic alkalosis. Hypokalaemia buys sildenafil australia the toxic effects of cardiac glycosides. Normally potassium ions compete with cardiac glycosides for their site of action, which is the NaK ATPase pump in the cardiac muscle cell membrane.

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