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- Increased incidence of fetal malformation, particularly cleft palate and cardiac malformation is suspected in epileptic mothers who take phenytoin.
- Stimulant laxatives are unsuitable for prolonged use because this can lead to excessive loss of potassium ions and a colon that no longer responds to stimulation.
- Published work in this area revealed that the role of the doctor was often unnecessary in the patient review process and, out of recorded activities to obtain medication for the relief of side effects from radiotherapy, there was only one case where the patient needed to be seen by a doctor.
- Many anthelmintics are available in the United Kingdom only on a named-patient basis.
- Drug absorption can be altered in older people for a number of reasons.
For many of these drugs the mode of action is not fully understood, but they all interfere with the activity of cells of the immune system in one way or another. Gold salts accumulate in phagocytic cells thereby reducing their activity and inhibit the migration of lymphocytes into inflamed tissue.
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For example, its effects are enhanced by ibuprofen and cimetidine (used to treat stomach ulcers) and reduced by phenytoin and alcohol. Heparin works by enhancing the formation of a complex of thrombin and antithrombin III. This effectively prevents thrombin from activating fibrinogen. Heparin has a rapid action of short duration and has to be given by injection. It is used to decrease the risk of deep vein thrombosis after surgery and during recovery from heart attack and stroke until warfarin becomes effective.
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Clomethiazole is used as a hypnotic for older patients because of its lack of hangover effect but it can still produce dependence.
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