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Repeated treatment is often necessary and can be painful. One preparation contains podophyllum, which is a cytotoxic drug and must not be used in patients who are pregnant or considering pregnancy or breast-feeding.

  • Development of a Limited Formulary Prescribing Scheme for Therapy Radiographers and Oncology Nurses NHS Executive RD Project Grant: Ref D Conference.
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Folic acid is the starting point for a cofactor necessary for DNA synthesis in both bacterial and human cells. However, in susceptible bacterial cells, folic acid must be synthesized, whereas in humans it is provided preformed in the diet. Sulphonamides interact with warfarin by enhancing the actions of these drugs. The most important adverse effects of sulphonamides are rashes, renal failure and various blood disorders. Trimethoprim inhibits another enzyme, dihydrofolate reductase, in the same folic acid metabolic pathway. Folic acid is converted into folate, which then has to be converted into an activated form by dihydrofolate reductase.


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