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These viruses use an enzyme called reverse transcriptase to copy viral RNA to produce viral DNA. The viral DNA is then incorporated into the host cells DNA where it can lie dormant before being used as a template for the production of more viral RNA.
- It is not based on pathology, diagnostic tests or the presence or absence of an immediate cause.
- Heart rate can be altered by the autonomic nervous system to meet changes in demand for blood supply.
- They are conveniently taken just before each main meal and have a rapid onset and short duration of action.
- This kind of use is now considered unsuitable.
- These bind bile acids in the intestine, increasing their excretion by preventing enterohepatic recycling.
- Open closed inactivated sodium ion channels local anaesthetic ionized local anaesthetic neuronal membrane diffusion Figure Local anaesthetics are weak bases and at the slightly alkaline pH of body fluids, they exist in both ionized and unionized forms in equilibrium.
Vitamin K antagonists block the activity of vitamin K resulting in the production of inactive clotting factors by the liver. They take a few days to have effect because circulating clotting factors already in existence have to be used up.
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This treatment can involve the supply and administration of medicines, particularly for pain relief. The current arrangements are that these radiographers work within PGDs.
Inhibition of COX by NSAIDs reduces rather than abolishes inflammation because the drugs do not inhibit production of other mediators of inflammation. Most patients experience some relief from pain, stiffness and swelling, but these drugs do not alter the course of the disease, prevent tissue destruction or produce remission. There are many drugs belonging to the NSAIDs group and the main differences between them are the incidence and type of side effects. Aspirin used to be the obvious first choice anti-inflammatory analgesic, but its use has been superseded by less the toxic drugs. Aspirin is more likely to be used as a short-term analgesic than an anti-inflammatory drug. Ibuprofen, fenbrufen and naproxen are now the drugs of first choice because they are the least likely to cause gastric irritation and ulceration, a common side effect of all NSAIDs.
If a drug is water soluble it is likely to remain in the blood stream and its volume of distribution will be relatively small and equal blood volume. Similarly, acidic drugs tend to bind to plasma albumin and therefore also remain in the blood stream and have a small volume of distribution. If a drug is highly lipid soluble, then it will be distributed to many parts of the body and have a large volume of distribution. In addition, basic drugs tend to bind to tissue proteins and as a result have a large volume of distribution. On entering the body, drugs are treated as if they are toxic substances, which need to be detoxified, if a mechanism exists, and eliminated as soon as possible. This means that most drugs are subjected to some kind of metabolism and then excreted.
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Class I calcium channel blockers are contraindicated in patients who already have these conditions. Class II calcium channel blockers act primarily on smooth muscle cells and as such lead to dilation of blood vessels.
03.09.2018
Helmut
Verified
Drug therapy includes the use of anticholinesterase drugs, anti-inflammatory corticosteroids and immunosuppressant drugs in resistant cases.
18.10.2018
Lina
Verified
Twin studies have shown concordance rates for bipolar depression of more than twins. Bipolar depression appears to be a complex genetic illness, with susceptible genes interacting with environmental factors and adverse life events.
29.11.2017
Gerlinde
Verified
Methotrexate inhibits an enzyme (dihydrofolate reductase) necessary for the synthesis of purine nucleotides (adenine and guanine), which are components of DNA. This results in a reduction in DNA synthesis and particularly affects rapidly dividing cells.
18.01.2017
Hannah
Verified
