Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete intercourse. Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction.

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They are both produced using the same active ingredient Sildenafil. The main advantage of Kamagra is the brand-like quality for a much lower price. Kamagra can treat all kinds of erectile dysfunction, from weak to severe. It is also effective in the treatment of psychological and physiological erection dysfunctions. So, if you are looking for a quality Sildenafil based drug in Malaysia to improve your sexual life, Kamagra is your choice! If you are searching for awesome product in Malaysia that belong to group of Sildenafil drugs to advance sexual potency, Kamagra should be unbeatable option at the end.

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In addition, drugs that reduce the availability of monoamines cause symptoms of depression. From such observations the monoamine theory of depression and mania was formed: Depression is due to an absolute or relative decrease in monoamines, or a decrease in receptor sensitivity, at certain receptor sites in the brain. Mania is due to an absolute or relative excess of monoamines or an increase in receptor sensitivity at these sites. Even after years of research, it is still not clear which receptor sites or which monoamines are involved, although noradrenaline, serotonin and dopamine are all implicated. Neither does the theory explain how mania and depression can exist in the same patient. Much research has involved investigation of cerebrospinal fluid, blood and urine of patients to see if there are any abnormalities of monoamine metabolites.

In an acidic environment, as in the stomach, acidic drugs are unionized according to the following simple equation: where A is an acidic drug and the excess hydrogen ions drive the equation to the left. In an alkaline environment, as in the small intestine and the majority of body fluids, basic drugs are unionized according to the following simple equation: where B is a basic drug and the deficit of hydrogen ions drives the equation to the right. Thus, acidic drugs are preferentially absorbed in the stomach and basic drugs are preferentially absorbed in the intestine. In practice however, because of the large surface area of the small intestine, the majority of drug absorption takes place there. Nevertheless, alteration of stomach pH can alter the absorption characteristics of acidic drugs. A few drug molecules are small enough to diffuse through aqueous pores in the cell membrane with water, for example alcohol.

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