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It is given orally and has anti-inflammatory and cytostatic actions. This is useful in inflammatory psoriasis. The half-life of acitretin is about two days.

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Other areas of research include the development of drugs that block the capacity of oncogenes to turn cells malignant; antagonists of growth factors; inhibitors of cell cycle control factors; and gene therapy to restore tumour suppressor gene function. Cancer occurs when mutated cells divide uncontrollably, taking up space and spreading to distant parts of the body. Treatment is usually with a combination of surgery, irradiation and chemotherapy. The aim of chemotherapy is to interfere with cell division in tumour cells without damaging normal healthy cells. However, because cancer cells are similar to normal cells, chemotherapy is toxic to rapidly dividing cells in bone marrow, hair follicles and the gastrointestinal tract.

An example of a proto-oncogene is the ras gene. This gene codes for a protein called Ras. Mutation of the ras gene leads to production of abnormal Ras, which activates cell division. Mutations of the ras gene are found in It is believed that normal growth within tissues is also controlled by contact inhibition.

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