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This led to the suggestion that idiopathic Parkinsons disease may be caused by some, as yet, unidentified neurotoxin. It is possible that overactivity of glutamate could cause neuronal damage [as may also be the case in motor neuron disease and Alzheimers disease]. Other known toxic causes include Wilsons disease, where there is deposition of copper in the basal nuclei, and mercury and manganese poisoning.
) The cause of motor neuron disease is unknown. There is one drug that can be used to slow the progression of motor neuron disease and extend life or prolong the time to mechanical ventilation. Riluzole inhibits the release and postsynaptic action of glutamate in the motor pathways. It is said to be neuroprotective and slows deterioration of nerve function. This could be because excessive amounts of glutamate are released in motor neuron disease and this is toxic to neurons.
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- This denatures the DNA and as a result transcription of DNA for protein synthesis and replication of DNA for cell division are disrupted.
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The effect is usually harmful and occurs in a very small proportion of individuals. It is due to factors peculiar to the individual that may be genetic in origin, but the mechanisms are usually poorly understood.
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Dehydration of endothelial cells of brain capillaries may allow diffusion of contrast agent into the brain. If this happens, the contrast agent may provoke seizures.
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Expiration is normally passive and happens when the muscles of inspiration relax and the elastic tissue of the lungs recoils. During exercise, expiration becomes forced involving the internal intercostal muscles and other muscles in the neck and abdomen. The rhythm of breathing is maintained by the respiratory centre in the brain stem.
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Nicorandil is an example of a potassium channel activator.
24.05.2019
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Once activated, the cell starts reading its DNA to make proteins. This includes making more viral RNA and viral proteins, which are assembled into new virus particles.
01.04.2018
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Inhaled corticosteroids are useful for treatment and prophylaxis of asthma and for reducing acute exacerbations of bronchitis.
20.07.2017
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The response to anti-cholinesterase drugs may take several weeks.
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Treatment repeated at three-week intervals.
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