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Sildenafil, which appeared on the market in the late 90s, is the first really effective drug that has helped solve the problem of erectile dysfunction to large number of men. According to statistics, about million men from 18 years and older suffer from problems in sexual life and urination due to the disorder of blood circulation in the pelvic. Thanks to a big advertising campaign and truly innovative features, the drug is known all over the world. Its high efficiency is specified by an incidental finding and synthesizing the compound — sildenafil — which acts selectively only for a particular process in the smooth muscle. In order to understand how Viagra works the mechanism of erection appearance and preventing factors should be examined.

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This analog has the same therapeutic effect. There are two main differences between generic vs brand: price and additional components. The price is the main reason why men prefer buying generic analog. Viagra is a drug intended for the treatment of erectile dysfunction. The essence of this medication lies in relaxing the blood vessels and magnifying the blood flow to the penis. Considering a recent examination, 2 out of 3 men who suffered erectile problems have noticed that the application of a PDE-5 inhibitor contributed to the erection improvement. Doctors prescribe taking sildenafil 30 minutes before the planned sexual intercourse. The active constituent is sildenafil. Available sildenafil dosages are 25, 50 or mg in one pill. But you may also buy individual Viagra dosages and even mg depending on what your physician prescribes to you.

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Viagra returns lost sexual function and assists in stable erect to the men. In order to have an erection, they should be completely filled with blood. An extensive network of small arterioles is inside these corpora cavernosa, which are filled with blood during relaxation of the muscles of the penis. This is only possible in the presence of nitric oxide. The drug Viagra inhibits PDE5 substance and provides the erection.

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Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete intercourse. Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes.

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The preparation recovers the normal reaction to sexual arousal. A physiological mechanism that ensures an erection is not possible without emitting of nitric oxide in cavernous body during sexual stimulation.

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Their 200mg viagra online depends on their ability to inhibit the activity and proliferation of lymphocytes and other leukocytes and because of this they are very toxic to the bone marrow. Other adverse effects are nausea, leukopenia, blurred vision, rashes and hair loss. Cytokines are chemicals released by damaged cells and cells involved in inflammation and repair. Drugs have been developed against two of them, tumour necrosis factor α (TNF-α) and interleukin and together they are key players in the inflammatory response. Levels of both are raised in rheumatoid arthritis and other autoimmune diseases.


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Although results may be complicated by diet, non-brain amines and the inevitable drug therapy, evidence indicates that bipolar depression is associated with a decrease in dopamine activity, mania with an increase in dopamine activity [or depletion of inhibitory gamma-amino butyric acid (GABA)] and unipolar depression with a decrease in noradrenaline or serotonin activity or both.

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The need for a book such as this one has arisen as a result of recent changes in legislation and expansion in the numbers of health care professionals involved in administration andor prescription of medicines. The book is an introduction to pharmacology for health care professionals.

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