Thank you for visiting nature. A Nature Research Journal. The process of finding new uses outside the scope of the original medical indication for existing drugs is known as drug repositioning. Repositioning existing drugs for new indications can offer a better risk-versus-reward trade-off as compared with other drug development strategies, and can help to deliver the productivity increases the industry needs while shifting the locus of production to biotechnology companies. Challenges unique to the repositioning field include: discovering and validating the repositioning idea in the face of incomplete or antiquated data and identifying the repositioning candidate; developing novel clinical trial designs for indications that have never been pursued before; identifying and overcoming patents that could impede commercialization and developing new barriers to entry strategies. Pharmaceutical companies might own most of the raw material for repositioned drugs, but the initiative and insight to screen them for novel uses usually comes from biotech companies, who possess the ideal combination of incentives to pursue new indications for existing drugs given their level of entrepreneurship, motivation succeed or die and institutional flexibility. Biopharmaceutical companies attempting to increase productivity through novel discovery technologies have fallen short of achieving the desired results.

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Industry-specific and extensively researched technical data partially from exclusive partnerships. This statistic was assembled from several of 's annual and financial reports. In, revenues for Viagra in the U. Therefore, in, total Viagra worldwide revenues were reported in EH. This feature is limited to our corporate solutions. Please see our privacy statement for details about how we use data. Premium statistics. Sales of this drug have decreased steadily over the past seven years, especially because patent protection expired outside the U.

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The maker of Viagra, the world's leading treatment for erectile dysfunction, has announced that it will start selling its product direct online, in an effort to counter the apparently unstoppable trade in counterfeit pills. Other drugs companies will watch the development with interest. Traditionally, drugs makers have not sold directly to patients, selling instead to wholesalers which distribute the drugs to doctors, hospitals and pharmacies. Viagra, which was launched in, became a global sensation, backed in the US by a wave of advertising featuring middle-aged men, including the soccer star Pele and senator Bob Dole, talking about ED, or erectile dysfunction. Counterfeit medicines often contain the wrong or incorrect levels of active ingredient, as well as potentially dangerous contaminants.

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Often dubbed the little blue pill, Viagra sildenafil was the first phosphodiesterase 5 PDE5 inhibitor approved to treat erectile dysfunction ED. ED is a common sexual problem for men and its frequency increases with age. It is estimated roughly 30 million men in the U. A large U. The sildenafil compound was originally developed by for the treatment of hypertension high blood pressure and angina pectoris chest pain due to heart disease. During the heart clinical trials, researchers discovered that the drug was more effective at inducing erections than treating angina.

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The ITA attributes an aging population, a rise in chronic disease rates, increased urbanization and higher disposable incomes, greater government expenditures on healthcare, and the demand for more effective treatments as reasons why drug sales are expected to soar globally through and likely beyond. This steady growth in both volume and pricing power, especially in the highly lucrative U. After all, if they can ride the coattails of a blockbuster drug higher, investors should be rewarded. Of course, figuring out what drugs have the potential to dominate an indication is easier said than done. Ongoing drug development from competitors could always push a promising drug out of the picture almost overnight.

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