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Examples of drugs originally from natural sources and still in use today are quinine, digitalis (from the foxglove and used for heart failure) and aspirin (extracted from the bark of willow tree and originally used to treat fever). Development of new drugs can happen in many ways. Drugs have been viagra canada online pharmacy following observation of side effects when being used for other purposes. As knowledge of receptor structures has developed, this has allowed drugs to be designed to fit with receptors. The human genome project and mapping of genes has led to work on the development of drugs to alter genes.

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Side effects of calcitonin are nausea, vomiting and diarrhoea together with flushing, paraesthesia and a peculiar taste in the mouth. The mechanism of action of bisphosphonates is not completely understood. They are deposited in place of normal bone and may slow bone turnover because they are resistant to degradation by enzymes produced by osteoclasts or they may inhibit the activity of osteoclasts. Bisphosphonates are given orally and about in bone. They should not be taken at the same time as milk because it impairs their absorption.


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This chapter describes some disorders of the central nervous system and the drugs used to treat these conditions.

29.12.2019
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The fibrous tissue reduces the strength of the bone and may lead to stress fractures, which are notoriously difficult to heal. Deformity of the bone(s) is common and may result in an alteration in gait.

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