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Others, however, can cause adverse effects as a result of their effects on normal healthy cells. Most antibiotics are effective against rapidly dividing cells. Bacteria are classified by gram staining into gram-positive and gram-negative bacteria.

(Lidocaine by virtue of the same mechanism of action is used as a local anaesthetic. Adverse effects of lidocaine are drowsiness, slurred speech, paraesthesia (pins and needles) and convulsions. Flecainide is an alternative to lidocaine for the treatment of ventricular arrhythmia and can be used orally for disabling paroxysmal atrial fibrillation. Adverse effects of flecainide are nausea, vomiting and precipitation of arrythmias.

Withdrawal from antiepileptic drugs should be gradual to avoid the risk of precipitating rebound seizures. It is not known exactly how antiepileptic drugs work, but two mechanisms seem to be important for drugs in current use, while newer drugs may work by other means yet to be elucidated. Many well-established antiepileptic drugs (for example phenobarbital and benzodiaze pines) are known to facilitate the opening of GABA chloride ion channels at synapses. However, this is not the complete explanation as, for example phenobarbital is far more effective as an anticonvulsant than other barbiturates with the same enhancing effects on GABA.

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