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There are four main receptor types based on the mechanism by which they exert their effects.
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Many of the general factors considered above that affect absorption from the gastrointestinal tract apply equally to this route of administration. Sublingual administration of a drug allows the drug to go directly into the systemic circulation without first passing through the liver.
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It is possible for drugs to move back across the intestinal wall by diffusion or active transport and be lost in faeces. Some drugs, particularly hormones, can also be excreted into the intestine via bile.
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