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It works by damaging the head of the tapeworm so that it can no longer attach to the inside of the intestine. Niclosamide has few side effects, but it has been superseded by praziquantel. Praziquantel is a highly effective anthelmintic, which induces muscular contraction and spastic paralysis in trematodes and cestodes by increasing calcium ion fluxes. Adverse effects are rarely of any clinical importance.

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In some patients, particularly those with HIV and on multiple therapy, more serious exfoliative dermatitis and StevensJohnson syndrome has occurred with fluconazole. Some imidazoles are known to interact with oral hypoglycaemic drugs by enhancing their activity and they may increase the risk of myopathy with lipid-lowering drugs statins. Some imidazoles enhance the anticoagulant properties of warfarin. Adverse effects with topical preparations are irritation and itching of the skin. Protozoa are microscopic single cell organisms, some of which can infect and cause disease in humans.

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