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Environmental factors that may play a role in the aetiology of Parkinsons disease include: living in a rural environment; using well water; exposure to pesticides; a diet high in animal fats or carbohydrates; or low consumption of foods rich in antioxidants such as vitamin C and E. Rarely, Parkinsonism can also follow head injuries, cerebral tumours and cerebral ischaemia. At post-mortem, brains of patients with Parkinsons disease are found to contain Lewy bodies. Lewy bodies are intra-neuronal inclusions and can be found throughout the brain and cerebral cortex. There appear to be three types of Lewy body disease: brain stem predominant and neocortical (associated with dementia). Cigarette smokers appear to be at a reduced risk of developing Parkinsons disease.

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Human cells contain a different form of DNA gyrase and so are unaffected by these drugs. Ciprofloxacin is a broad-spectrum antibiotic, active against both Gram-positive and Gram-negative bacteria.

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A basic knowledge of the characteristics of these organisms is needed in order to understand how they differ from human cells and how these differences can be exploited in chemotherapy.

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