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Many of the same types of drugs are used to treat different rheumatic diseases. NSAIDs are used in the treatment of chronic inflammation because they have a lasting analgesic action and an anti-inflammatory effect. Both of these effects are due to the inhibition of an enzyme, cyclo-oxygenase. This enzyme normally converts arachidonic acid to prostaglandins, thromboxanes and prostacyclin.
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When a nerve impulse arrives at a synapse, chemical substances are released. These are neurotransmitters, which are stored in pre-synaptic vesicles. On release they cross the synaptic cleft and bind to receptors on the post-synaptic neuron.
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This is essential not least because information about drugs and associated legislation is constantly changing. New drugs come on the market, and others are withdrawn or reclassified. Reliable sources of information are the British National Formulary, the British Pharmacopoeia and summaries of product characteristics supplied by medicines purchase diazepam online. Official bodies concerned with the use, quality and safety of medicines are the Commission on Human Medicines, the Medicines and Healthcare Products Regulatory Agency and the National Institute for Health and Clinical Excellence.
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Lipid-soluble drugs may be reabsorbed in this way and as a result, they are eliminated slowly from the body. Metabolism of drugs tends to make them less lipid soluble, more water soluble and therefore more likely to ionize. Tubular filtrate is normally slightly acid and this favours the excretion of basic drugs because they ionize more readily in acidic conditions and therefore do not diffuse easily back into plasma.
These adverse drug reactions are generally dose-related and most can be predicted. They can be caused by an exaggeration of a drugs intended pharmacological effect or by an unwanted action or side effect. Type A adverse reactions are most likely to occur with drugs that have a steep doseresponse curve andor small therapeutic ratio. The TR of a drug is the ratio of the maximum non-toxic dose to the minimum dose that has a therapeutic effect and is essentially a measure of a drugs safety margin. TR maximum non-toxic doseminimum effective dose The most dangerous drugs are those with a small TR where the maximum non-toxic dose is very close to the effective dose.
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Loprazolam, lormetazepam and temazepam have a shorter duration of action and little or no hangover effect. As a rule, benzodiazepines should be used to treat insomnia only when it is severe, disabling or subjecting the individual to extreme distress.
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Diuretics are used to treat cardiac failure and hypertension. ACE inhibitors and angiotensin II receptor inhibitors limit the action of angiotensin II and suppress aldosterone production.
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Cellular energy in the form of ATP is required to drive the process and transport goes against the concentration gradient. By such a mechanism, substances can be concentrated in certain parts of the body.
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