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Phase substances by conjugation with endogenous compounds in the liver. This too encourages renal excretion. The most important conjugation reaction is with glucuronic acid to form a glucuronide.

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All increase the risk of hypoglycaemia. The mechanism is probably competition for metabolizing enzymes or displacement from plasma protein binding sites. Drugs that decrease the effectiveness of sulfonylureas include diuretics and corticosteroids. There are three other groups of drugs licensed in the United Kingdom for the treatment of NIDDM.

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