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Adverse reactions to drugs can be divided into type A and type B (bizarre). These adverse drug reactions are generally dose-related and most can be predicted. They can be caused by an exaggeration of a drugs intended pharmacological effect or by an unwanted action or side effect. Type A adverse reactions are most likely to occur with drugs that have a steep doseresponse curve andor small therapeutic ratio. The TR of a drug is the ratio of the maximum non-toxic dose to the minimum dose that has a therapeutic effect and is essentially a measure of a drugs safety margin.
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An inhibitor of GABA has not been identified, but it has been tentatively called GABA modulin.
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