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None of the patients who received diazepam required emergency room treatment. Best Value! This difference was noted as early as 30 minutes after the initial dose and continued throughout the diazepam gel cost period. The authors conclude that rectal diazepam gel is safe and effective for acute repetitive seizures and can be administered by caregivers who know how to monitor the person's response. The period of observation and data recording by caregivers began immediately after the first dose and continued for 12 hours in children and for 24 hours in adults.

They are safe and they work quickly. No instances of respiratory difficulty occurred. Dreifuss FE, et al. Earn up to 6 CME credits per issue. Rectal diazepam gel was administered in dosages of 0. Am Fam Physician. Diazepam gel was found to be significantly more effective than placebo in reducing seizure frequency in both adults and children.

A comparison of rectal diazepam gel and placebo for acute repetitive seizures. Navigate this Article. However, oral administration is often difficult in a patient who is actively convulsing. Caregivers were taught how to identify repetitive seizures, administer diazepam rectally, and monitor and record respirations, skin color, seizure activity and adverse events.

Nov 1, Issue. A second dose was given four hours after the first and, in adults, a third dose was given eight hours after the second dose. The study included 91 patients aged two to 60 years who had had at least four episodes of repetitive seizures during the preceding year and at least one such episode in the previous three months. The caregiver's global assessment of the treatment outcome was significantly higher for children receiving diazepam than for children receiving placebo, but no significant difference was observed in this outcome variable for adults in either group.

Benzodiazepines are the drugs of choice for the treatment of acute repetitive seizures. N Engl J Med. June 25, ;—75, and Vining EP. June 25, ;—8.

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