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An outline of normal physiology of the systems is included where appropriate and relevant diseases described briefly. This is not intended to be a physiology book or a pathophysiology book. Should the reader need to consult such books, suggestions are given in the bibliography. Major groups of drugs are discussed, with emphasis on areas of relevance to the three professions for whom the book is intended. In addition to drugs used to treat diseases of the major systems, the treatment of infections and parasites, the use of cancer chemotherapy, the use of anaesthetics and analgesics and the use of contrast agents and adjuncts to radiotherapy are included in Part The final part has two chapters.

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This gene codes for a protein called Ras. Mutation of the ras gene leads to production of abnormal Ras, which activates cell division. Mutations of the ras gene are found in It is believed that normal growth within tissues is also controlled by contact inhibition. That is, inhibition of abnormal cell division and growth by cell-to-cell contact factors called integrins and adhesion molecules. In addition, as cells are added during growth and repair, others die so overall size of a tissue or organ is maintained.

Would you recommend any changes to the patients treatment regime. Are there any alternative medicines that could be tried for the neuropathic pain. Do you think this patient would be suitable for treatment under patient group directions or supplementary prescribing. You should be able to answer the following review questions from the material presented in this chapter. Radio-opaque substances are used in various ways to facilitate radiological examination of parts of the body. They are known as contrast agents or contrast media and are usually based on iodine, barium or gadolinium containing compounds.

They are understandably anxious about their sons treatment and ask you about potential side effects they can expect with chlorambucil. What can you tell them about this drug and its side effects. Johns parents are keen to know how else they can help their son. They ask you for advice about making sure John eats well. How can you advise them about nutrition. During your consultation with John and his family, you notice that John has said very little.

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