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Reactive depression is usually associated with stressful life events, whereas endogenous depression is a persistent alteration of mood with no obvious cause. However, this classification has largely been abandoned because there is often overlap between the two. For example mild so-called reactive depression can occur without an obvious change in circumstances. Amongst psychiatrists one of two diagnostic classifications are now used. These are the International Classification of Diseases (ICD- Revised.
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Cortisol derived drugs are used therapeutically for their anti-inflammatory and immunosuppressant actions. There are several disorders of the adrenal glands. Hypersecretion of aldosterone (Conns syndrome) is treated with an aldosterone antagonist. Hypersecretion of cortisol (Cushings syndrome) and testosterone are managed with surgery or irradiation.
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Adverse reactions to anti-inflammatory corticosteroids are summarized This is a diverse group of drugs that do not inhibit COX; neither do they have analgesic or direct anti-inflammatory activity. They appear to suppress the disease process in rheumatoid arthritis and other chronic inflammatory conditions and may cause remission of disease. These are the disease-modifying antirheumatic drugs. Unlike NSAIDs and corticosteroids, they do not produce an immediate therapeutic effect but require four to six months of treatment for a full response.
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Sequestration in this way gives an apparent large volume of distribution but also means that only a small proportion of total drug concentration will reach its site of action.
13.09.2020
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Adverse effects of thyroxine therapy are due to overdose and are essentially those seen with hyperthyroidism together with the risk of angina, cardiac arrhythmia or cardiac failure.
03.04.2016
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Supplementary prescribing is intended to improve patient access to the care and medicines that they need.
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Oral griseofulvin is prescription-only and is indicated where topical therapy is ineffective but it has largely been replaced by the newer imidazole antifungals.
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