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However, they contain fewer radio-opaque iodine atoms and therefore are less effective as contrast agents. The higher the concentration of iodine in a contrast agent the greater is the positive radiographic contrast that can be achieved. The latest non-ionic dimeric contrast agents have six iodine atoms per molecule. Some are nearly isosmolar with plasma, others are hypo-osmolar and they have very low toxicity. Because of this low toxicity, they are used most often nowadays, although monomeric, ionic meglumine ioxaglate is said to cause less pain and heat on injection.
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Treatment is with prescription-only medications and is not considered here.
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In these cases symptoms may be produced through stimulation of irritant receptors and release of mediators from sensory neurones.
10.02.2016
Franz
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