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Anti-cholinergic drugs were originally used prior to the development of levodopa because many signs of excessive parasympathetic activity are seen in Parkinsons patients (salivation, sweating and incontinence). The basal nuclei contain many excitatory cholinergic neurons.

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Chronic pain is thought to be associated with changes to the normal physiological pain pathway. The pathway for pain perception is a chain of three neurons.

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