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Nurse independent prescribers, pharmacist independent prescribers and supplementary prescribers can write prescriptions for POM. Given below are examples of the types of drug that are POM: Any drug controlled by the Misuse of Drugs Act codeine, dihydrocodeine, morphine or pholcodeine subject to only one of these being in a product AND that it does not exceed a certain strength Certain specific items, for example radiopharmaceuticals All products for administration by injection All other listed drugs in the order unless there tramadol medication cost specific exemption, for example when given by a certain route or when in low concentration. POM may only be administered by the patient, a practitioner or someone acting in accordance with the directions of a practitioner. The Prescription Only Medicines Order non-injection drugs to the patient for which they are intended and in the manner prescribed. Normally, drugs for injection can only be administered by the patient or by a medical practitioner. However, in an emergency, when used for the purposes of saving life, certain drugs may be administered parenterally by anyone.

The independent prescriber will determine the level of responsibility the supplementary prescriber has under the CMP. This will take into account the experience and expertise of the supplementary prescriber. The CMP would come to an end at any time at the discretion of either the independent prescriber or the supplementary prescriber or at the request of the patient. It must also be renewed at the time specified for review of the patient or if the independent prescriber changes for whatever reason. Supplementary prescribing must not continue until a new agreement has been made with the patient and a new independent prescriber. Any GSL, P or POM medicine (including controlled drugs since July where there is a patient need and the doctor has agreed in a patients CMP) can be prescribed under a CMP.

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Tubular secretion of drugs occurs in the proximal convoluted tubule by active transport mechanisms normally used for the removal of waste products. Transport systems exist for the secretion of acidic substances, for example uric acid and basic substances, for example creatinine. Many drugs can be actively secreted by this mechanism, which increases their rate of removal from the body. Active transport does not depend on concentration gradients and can overcome plasma protein binding. As the free drug is transported, more of the drug dissociates from the protein binding site and can be eliminated.


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In order to avoid this it is good clinical practice for drug dosages to be checked by another member of staff prior to administration.

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