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Cortisol also has anti-inflammatory and immunosuppressive actions, which under physiological conditions help to limit response to injury and infection. When used pharmacologically, these effects are useful in treating chronic inflammatory conditions. The inner layer of the cortex produces adrenal androgens, the main one being testosterone. Adrenal androgens are produced in both sexes and are responsible for the development of secondary sexual characteristics that occur at puberty. In males, the testes also secrete testosterone. Disorders of all parts of the adrenal glands are possible.

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Erythromycin in particular can increase the risk of myopathy if taken in combination with lipid-lowering statins. Such combinations should be avoided. Adverse effects of macrolides are nausea, vomiting, diarrhoea, deafness (with high doses but reversible) and jaundice. Chloramphenicol also binds to the Resistance to chloramphenicol occurs due to activity of bacterial enzymes. Because it is extremely toxic to bone marrow, its use is reserved for life-threatening infections where no other antibiotic is effective.

It is important for health care professionals to be aware of potential adverse effects of drugs and to know how to report new ones when they occur. Apart from the possibility of adverse drug reactions occurring, individuals show variation in response to drugs and this is particularly likely in the very young and the very old. In order to have an effect on the body, therapeutic, adverse or otherwise, a drug must interact with its site of action. Sites of action are known as targets for drug action and include receptors, ion channels, enzymes and carrier molecules. The study of the effects that drugs can have on the body and how they produce these effects is known as pharmacodynamics. An adverse reaction is any reaction to a drug that is harmful to the patient.

Air enters the nose through two openings, the nostrils. The nasal passages are lined with a moist hairy mucous membrane that traps dust, dirt and bacteria breathed in with air. As air passes through the nasal passages it is also warmed and moistened. The epiglottis is a flap of cartilage that closes the trachea during swallowing. The larynx is situated in the pharynx at the top of the trachea.

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