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In fact, what we really need are several hierarchies, which suit the different research questions we are likely to come across. Whilst the data collected from questionnaires can be unreliable, in this instance, there is really no other way to get at this data. Liver injury and teratogenicity are major concerns and require monthly monitoring. One study, PhosphodiesterasE-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure Study, is currently enrolling participants to study the effect of sildenafil in patients with diastolic heart failure.
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