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Examples are amlodipine and nifedipine. Nifedipine also has a use in the treatment of Raynauds disease. In Raynauds disease, there is inappropriate vasoconstriction in the fingers and toes, usually in response to cold. The condition can be mild or severe leading to ulceration and possibly gangrene of the digits. Raynauds disease can occur on its own, or as a consequence of systemic sclerosis or systemic lupus erythematosus, both chronic inflammatory diseases.

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You should be able to answer these review questions using the information covered in the preceding chapter. There are many diseases and conditions affecting the musculoskeletal system; many of them are rare and certainly too numerous to include here. The following diseases have been chosen, either because they are relatively common or because they are of particular interest or relevance to podiatrists, physiotherapists or radiographers. Rheumatic diseases are chronic inflammatory diseases primarily affecting the joints, but with involvement of other tissues and organs. Gout is included as a chronic inflammatory joint disease and osteoarthritis as a chronic degenerative plavix buy disease.

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