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A case is presented of a patient diagnosed with attention deficit disorder, obsessive thinking, anger outbursts, and depression who had a SPECT study prior to treatment and after 3 years of treatment on clomipramine. New York: Raven Press; — Arch Neurol ; 41 8 — Am J Psychiatry ; — J Am Acad Child Psychiatry ; — J Clin Psychiatry ; —

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The treatment recommendations in obsessive-compulsive disorder OCD after lack of response to selective serotonin reuptake inhibitors SSRIs include augmentation with other drugs, particularly clomipramine, a more potent serotonin reuptake inhibitor SRI, or antipsychotics. The first patient had eleven years of treatment with multiple combinations including clomipramine and SSRIs. The second patient had 22 years of treatment with multiple combinations, including combinations of SSRIs with clomipramine and risperidone. These two patients were characterized by lack of response to multiple treatments, making a placebo response to lamotrigine augmentation unlikely. Until these trials are available, our cases suggest that clinicians may consider lamotrigine augmentation in such treatment-resistant OCD patients. The recommendations after lack of response to SSRIs are not so well established but usually include augmentation with other drugs: 1 particularly clomipramine, a more potent serotonin reuptake inhibitor SRI, or 2 antipsychotics. More recently, augmentation with glutamatergic agents has also been recommended. Lamotrigine is an antiepileptic drug and mood stabilizer that has antiglutamatergic properties and has been occasionally used in OCD treatment.

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Unfortunately haven't had any luck with this, only upsetting side effects which caused the psychiatrist to tell me to stop taking it. Also ineffective for the depression that I have alongside the OCD. I was on mg. The worst side effects were the sweating and the weakness weak when standing up. The other side effects: Dizziness, fatigue, difficulties speaking, excessive sweating, tingling h

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Sort by: Most recent Helpfulness Most Recent. Jun 29, Started Jul anafranil 225mg, Effectiveness. Can't tell for persistent depressive disorder dysthymia. Moderate for obsessive-compulsive disorder. Moderate blurry vision, dry mouth, dry eyes. Not at all hard to take.

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Side effects to discontinuing serotonin reuptake inhibitor SRI treatment are common and may be severe. Educate your patient about potential side effects to mitigate problems such as relapse or patient distress.

  • The objective of this study was to investigate, in a single-blind manner over a period of 12 weeks, the efficacy and tolerability of venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder OCD.
  • Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders.
  • Initially, 50 mg PO 3 times a day; may increase to mg PO 3 times a day in 1 week based on efficacy and tolerability.
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